Putting Cyclin E in the trash
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منابع مشابه
Putting Cyclin E in the trash
Putting Cyclin E in the trash L u and Pfeffer uncover a protein that helps remove Cyclin E after it has outlasted its usefulness. Cyclin E pushes cells from G1 into S phase. But if the protein lingers in cells, they can’t progress normally through the rest of the cell cycle. During S phase, the SCF pathway directs phosphorylated Cyclin E to the proteasome for destruction. A second, little-known...
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Cyclin E Ablation in the Mouse
E type cyclins (E1 and E2) are believed to drive cell entry into the S phase. It is widely assumed that the two E type cyclins are critically required for proliferation of all cell types. Here, we demonstrate that E type cyclins are largely dispensable for mouse development. However, endoreplication of trophoblast giant cells and megakaryocytes is severely impaired in the absence of cyclin E. C...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2032iti1